HIV vaccines: where are we now?
نویسنده
چکیده
©FFPRHC J Fam Plann Reprod Health Care 2007: 33(4) Introduction Human papillomaviruses (HPV) are a large family of small double-stranded DNA viruses that infect squamous epithelia (or cells with the potential for squamous maturation) including the skin and the mucosae of the anogenital tract and upper respiratory tract. More than 100 HPVs have been isolated from clinical biopsies. HPVs are classified by DNA sequence and numbered in the sequence in which they were isolated (e.g. HPV 1, HPV 2, etc.). Some 30–40 HPVs regularly or sporadically infect the genital tract and here they fall into two groups: low-risk viruses such as HPV 6 and 11 that cause genital warts and high-risk viruses associated with anogenital cancer. Infection with one of a subset of 15 high-risk HPVs is the main cause of invasive cervical cancer, but two types – HPV 16 and HPV 18 – cause more than 70% of carcinoma cervix, with HPV 16 detected in more than 50% and HPV 18 in 7–20% of cases (irrespective of the geographical location).1 Although cervix cancer is the major consequence of oncogenic HPV infection, a proportion of cases of carcinoma of the penis, vulva, vagina, anus and oropharynx are attributed to HPV, with HPV 16 being the major player. Overall, it is estimated that HPV is the cause of 3.7% of all cancers, making this a seriously important human carcinogen.1
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عنوان ژورنال:
- The journal of family planning and reproductive health care
دوره 33 4 شماره
صفحات -
تاریخ انتشار 2007